Software Raid 10? Presuming the System is booting from a non-software raid partition (Since it has to load the raid partition) theoretically it should.
But since Raid SATA and SAS controllers from Intel and Promise have gotten pretty expensive I wouldn't bother playing with it myself.
Cool but hardware kicks better.
Of course now that Terabyte drives are out, a pair of those mirrored should be interesting and nice a simple.... 